Dr Jo Wilson (Camilla Luddington) is beautiful, brilliant and funny, but boy does she have bad luck when it comes to love interests leaving abruptly on 'Grey's Anatomy'. First, it was Jo's husband Alex Karev (Justin Chambers), who left in one of the most incomplete exits the show has ever had to reunite with Izzie Stevens ( Katherine Heigl). At least with Karev's departure, Jo had plenty of sympathy coming her way. However, with Dr Jackson Avery's (Jesse Williams) departure to Boston, fans seemed to have forgotten that she and Jackson were even an item, a casual one at that, but still. 

But as the implications of Jackson leaving the show has begun to sink in and the feverish excitement of Japril end game has settled, fans have started to think about where this all leaves Jo. 

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One fan on YouTube said, "I'm really happy for jackson and his well-deserved storyline exit but mannnn jo getting left again with an ex-wife is still so funny." Others had a more sympathetic reaction, with one fan on YouTube saying, "I feel sad for JO.. Someone is leaving her again".

But Jo isn't the only one getting fans sympathy. Fans hearts are breaking for Meredith who is losing yet another friend, after she has just clawed her way back to health. A fan on YouTube said, "Jackson and Meredith friendship is underrated and one on my absolute favorites, I will definitely cry during their goodbye😢"

Fans now feel this is the perfect opportunity for Meredith and Jo to get closer. One fan on YouTube said, "The fact the April and Jackson are probably getting back together makes me forgive her for killing Andrew. If Jo ends up being pregnant with his kid i will riot."

Well, that would certainly add a twist and knowing the writers on 'Grey's Anatomy' it's not impossible. To find out what is the road ahead for Jo and Meredith, you can catch the latest episode of 'Grey's Anatomy' on Thursday at 9 pm on ABC.