'Grey's Anatomy' Season 16: No more Alex Karev, what will happen to Jolex now?

Alex and Jo's adorable pairing had been one of the strong points of the show, and now without that, where would Jo's storyline go?
Justin Chambers  as Alex Karev and Camilla Luddington as Jo Karev (IMDb)
Justin Chambers as Alex Karev and Camilla Luddington as Jo Karev (IMDb)

'Grey's Anatomy' is known for unceremoniously killing off characters, or giving them quick and summary exits. Fans have had to let go of Derek 'McDreamy' Shepherd (Patrick Dempsey), George O' Malley (TR Knight), Izzie Stevens (Katherine Heigl), Mark Sloane (Eric Dane), Lexie Grey (Chyler Leigh), among others as well-loved. And now, to join the list is Alex Karev (Justin Chambers). After the actor announced that he would be leaving the show after sixteen years, a current of anxiety erupted over social media and fans wondered how his exit will be dealt with on the show.

Moreover, what happens to his wife Jo Karev (Camilla Luddington)? The couple had just gotten through another difficult and hellish patch. The previous episode saw Jo kidnapping a baby from a care home. It would have been interesting to see how Alex would have responded to this unusual situation, and how it would affect their relationship. Except, we might not get to see that. Alex and Jo's adorable pairing (though fans debate it, and they still want to see him with Izzie) had been one of the strong points of the show, and now without that, where would Jo's storyline go?



 

It has been a long and painful road for Jolex, and they've broken up several times over the past few years. Well, they seem to have had an equal amount of proposals as well. Things really seemed to end for them, when Alex beat up Andrew DeLuca, because he thought that he was hurting Jo. Alex was subsequently jailed and brought out (because er, who stays in jail in 'Grey's Anatomy') and the two later reconciled. They've managed to stick by each other through thick and thin. True, they're arguably a little lacklustre, compared to Alex's chemistry with Izzie, but man, we'll miss these two. In the last episode, we saw a car crash, we're fervently hoping that it isn't Alex. 

So, what will happen to Jo? Fans are not going to accept her with anyone else.

'Grey's Anatomy' airs on Friday, January 23, at 8 pm, on ABC.

GET THE BIGGEST ENTERTAINMENT STORIES
STRAIGHT TO YOUR INBOX.

MORE STORIES

ABC’s 2026 schedule moved 'High Potential' while renewing all scripted shows and adding 'The Rookie: North.'
2 hours ago
Diane Sawyer’s ABC special explores Richard Simmons' mysterious disappearance, planned comeback, and hidden final years.
6 hours ago
Bernthal penned the script for 'The Punisher: One Last Kill' himself, working alongside Reinaldo Marcus Green, who also directed the special.
7 hours ago
'NCIS' Season 23 finale revisits a deadly bombing as Kayla Vance returns and McGee bonds with his newly revealed son, Mateo.
8 hours ago
'The Late Show with Stephen Colbert' has been a staple of late-night television on CBS since September 2015.
11 hours ago
Prime Video dropped an explosive promo of 'The Boys' Season 5 Episode 7 ahead of its May 13 premiere
15 hours ago
Season 2 was titled 'Jury Duty Presents Company Retreat,' and it followed Anthony Norman, who was hired as a temp
15 hours ago
The gritty spy thriller premiered in 2022, was one of Prime Video's bona fide hits, and will return this fall.
16 hours ago
The standalone special closes out the second season of 'Daredevil: Born Again,' which aired its finale last week on May 5
16 hours ago
The show ends with Calvin and Tina bidding an emotional farewell to the Johnsons
17 hours ago